University of Southern California


NIH – Limited Competition for the Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U01) RFA-DK-11-502


The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD.  Since its establishment, the IBDGC, in collaboration with other international IBD genetics consortia, has identified more than 100 such susceptibility loci.  However, many susceptibility genes still remain to be identified, and the work of elucidating how IBD risk-associated genetic variants influence the pathophysiology of IBD has barely begun.  The purpose of this FOA is to renew the IBDGC to continue the discovery of susceptibility variants, and to integrate genomic with epigenomic, transcriptomic, proteomic, metabolomic, and other -omic methodologies to elucidate the effects of genetic risk variants on the pathophysiology of IBD.  The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in accompanying RFA-DK-11-032), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and immortalization of cell lines, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees.  The PD(s)/PI(s) of the DCC shall serve as a voting member of the Steering Committee of the IBDGC, and be bound by all of the operational decisions of this Committee.

NIDDK intends to commit $1,250,000 in FY 2012 to fund one award.
The maximum application budget is $900,000 direct costs per year, and the maximum project period is 5 years.

Program Information

Institutional Limit
One proposal as the lead organization.


Internal:  Contact the Office of Research if interested.
Full Proposal:  4/30/2012

Nomination Process

Interested faculty should contact their school’s dean of research who coordinates the first step in the internal selection process. Faculty are typically asked to submit, at a minimum, a CV or biosketch, as well as a single-page proposal summary to their research dean.  Individual schools’ deadlines are in advance of the internal deadline posted above.  Check with your school for details concerning the nomination process.