University of Southern California


NIH – NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01) RFA-DK-11-032


The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD.  Since its establishment, the IBDGC, in collaboration with other international IBD genetics consortia, has identified more than 100 such susceptibility loci.  However, many susceptibility genes still remain to be identified, and the work of elucidating how IBD risk-associated genetic variants influence the pathophysiology of IBD has barely begun.  The purpose of this FOA is to renew the IBDGC to continue the discovery of susceptibility variants, and to integrate genomic with epigenomic, transcriptomic, proteomic, metabolomic, and other -omic methodologies to elucidate the effects of genetic risk variants on the pathophysiology of IBD.  The GRCs will serve as sites of enrollment of IBD patients, relatives, and healthy controls for these studies, and for laboratory-based studies on biological samples taken from these subjects.  The PD(s)/PI(s) of the GRCs will serve as members of the Steering Committee of the IBDGC, which will be responsible for all of the IBDGC’s operational decisions, which will be binding upon all of the IBDGC’s members.

NIDDK intends to commit up to $2,250,000 in FY 2012 to fund up to six awards. Application budgets are limited to $250,000 direct costs per year. And the maximum project period is five years.


Program Information

Institutional Limit
One proposal as the lead organization.


Internal:  Contact the Office of Research if interested.
Full Proposal:  4/30/12

Nomination Process

Interested faculty should contact their school’s dean of research who coordinates the first step in the internal selection process.  Faculty are typically asked to submit, at a minimum, a CV or biosketch, as well as a single-page proposal summary to their research dean.  Individual schools’ deadlines are in advance of the internal deadline posted above.  Check with your school prior to our internal deadline for details concerning the nomination process.