University of Southern California


RFA-HL-14-028 – Blood and Vascular Systems Response to Sepsis (R01)

Slots: One                      
Nomination per School:               One
Proposals may not be submitted directly by the PI; nominations are submitted by the School’s Research Dean’s Office.    

LOI:                                                        January 6, 2014 (Not required) 
Internal Deadline:                           December 16, 2013
External Deadline:                          February 6, 2014
Award Information:                        Type:  New
Estimated Number of Awards: The NHLBI intends to commit $22 million and the NIGMS intends to commit $13 million over 5 years to fund up to 8 awards.
The following NIH components intend to commit the following amounts in FY 2014: NHLBI, $4,400,000, to fund up to 5 awards.
NIGMS, $2,600,000, to fund up to 3 awards.
Anticipated Amount: An applicant may request a budget for direct costs up to $500,000 per year, excluding 1st tier subcontractor or consortium facilities and administrative (F&A) costs. The total project period may not exceed 5 years.

Materials to Office of Research: Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt).
CV – (4 pages maximum)

Link to Award:

Purpose: The goal of the Blood and Vascular Systems Response to Sepsis (BVSS) Program is to foster the multi-disciplinary research projects needed to unravel the cellular and molecular mechanisms underlying the development of severe endothelial dysfunction that contributes to sepsis-related coagulopathy and vascular collapse. The purpose of this initiative is to develop a new scientific framework for the prevention of sepsis related morbidity and mortality by applying novel approaches to restore vascular integrity through the discovery of new targets for biomarkers and therapy translation in blood and vascular systems. This initiative seeks to address this gap by supporting collaborations that pave the way for the identification of new treatment targets, pathways to target validation, and development of innovative anti-sepsis therapeutics.

This initiative will utilize the multi-PD/PI mechanism to ensure a sepsis-focused multidisciplinary research approach. Applicants must propose a single project with at least two multi-disciplinary PDs/PIs.  The research partnership could be across disciplines including hematology, cardiology, critical care, infectious diseases, cell biology, molecular biology, vascular biology, physiology, chemistry, biochemistry, microbiology, immunology, genetics and structural biology.  Applicants should also include a comprehensive multi-PD/PI leadership plan that addresses strategies for active multi-disciplinary collaborations.  The research project team members do not necessarily have to be located in the same institution or geographical location since desired combinations of expertise and technologies may not reside at a single institution or even a particular region of the country.  The inclusion of new and early stage investigators is encouraged.