RFA-OD-14-001 NIH Botanical Dietary Supplement Research Centers (BDSRC) (P50)
Slots: One per Institution
Nomination per School: One
Proposals may not be submitted directly by the PI; nominations are submitted by the School’s Research Dean’s Office.
LOI: April 6, 2014 (Not Required)
Internal Deadline: March 3, 2014
External Deadline: June 6, 2014
Award Information: Type: New/Renewal
Estimated Number of Awards: The number of awards is contingent on NIH appropriations and the submission of a sufficient number of meritorious applications. ODS and NCCAM intend to commit an estimated total of not more than $10 million per year in total costs to support up to five awards.
Anticipated Amount: Application budgets may not exceed $1.25 million in direct costs but need to reflect the actual needs of the proposed project. The scope of the proposed project should determine the project period. The maximum project period is 5 years.
Materials to Office of Research: Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). CV – (4 pages maximum)
Purpose: This FOA seeks to enhance progress in the understanding of complex botanical preparations used for human health by supporting the development, or deployment from other fields, of cutting-edge techniques or approaches that will accelerate progress in botanical research, including contributing to the ability to rapidly assess the identity and potential of a botanical product for specific health-related bioactivities or for within or inter-product interactions. The renewed Botanical Dietary Supplements Research Centers Program is expected to significantly advance human or other animal health-related botanical research through multi-component, transdisciplinary Centers that bring together projects with the potential to contribute to one or more of the following objectives:
- Development or adoption from allied fields of cutting-edge approaches with the potential to accelerate, improve predictive accuracy, or extend the capacity of methods for botanical identification and characterization, identification or prediction of toxicity, drug interactions, and/or efficacy.
- Elucidation of interactions between chemical constituents within a given plant, or between constituents of plants commonly used in combination, that are significant for their effects on human biology. Relevant outcomes may include, but are not limited to bioavailability, distribution, metabolism, safety/toxicity, mechanism of action, and efficacy.
- Development of in silico, in vitro and/or preclinical in vivo models to accelerate and/or enhance understanding of the activities and mechanism(s) of action of chemically complex botanical preparations. Research using in silico models must be closely integrated with parallel research in vitro or in animal models to ensure and validate the biological relevance of the combined approaches.
- Development of optimized approaches to obtain clearly interpretable outcomes of strong potential clinical relevance from studies of complex botanical mixtures.
- Development of approaches to assess the modulation of botanical activities (including metabolism, safety and efficacy) by host characteristics such as genetics, epigenetics and environmental exposures (including, but not limited to, the gut microbiome).
Preclinical projects focused on botanicals with a substantial history of human use, especially those used for health maintenance or improving resilience, are strongly encouraged, especially where focused on objective, quantitative outcomes with clear relevance to human health or resilience. Appropriate and translationally meaningful use of in silico, in vitro, and preclinical in vivo models, including invertebrate models, is strongly encouraged. At least one third of the Research Project specific aims should be focused on botanicals as they relate to resilience or health maintenance. These specific aims may be distributed among the proposed Research Projects as the investigators believe best suits the proposed research.
We anticipate that conduct of this research will include and entail:
- Application of state-of-the-art approaches, as well as the development of new methods or adaptation of cutting-edge methodologies from allied fields. Where applicable, validated methods and standard references materials such as those available via ODS’ Analytical Methods and Reference Materials Program should be used.
- Providing an environment suitable for the training of investigators able to design, conduct and participate in transdisciplinary botanical research, and coordination with funding approaches that provide training support.
- Interaction with the Center(s) for Advancing Natural Products Innovation and Technology (CANPIT) (RFA-AT-14-006).