University of Southern California

Research

Translational Research & Clinical Trials

SC CTSI-Southern California Clinical and Translational Science Institute

The SC CTSI is one of 60 NIH-funded Clinical Translational Science institutes with a mandate to increase the efficiency and quality of translational research. Services include: biostatistics and bioinformatics, education, career development, and ethics; clinical translation / clinical trials unit; preclinical translation and regulatory support; continuous quality improvement, research development and translational research informatics. The institute also works in partnership with core facilities at USC including: animal care and resources; cell culture; cytometry; genomics; histology; imaging; proteomics; therapeutic design, discovery & development; transgenic/knockout mouse in vivo models and vector design and construction.

Health Sciences Campus
Clinical Science Center
2250 Alcazar Street, CSC 200
Los Angeles, CA 90033
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Diabetes and Obesity Research Institute (DORI) Clinical Services Core

The DORI Clinical Services Core provides expert obesity- and diabetes-related clinical services to researchers. Services and equipment include: scans and analyses of DEXA, BodPod, MRI, Oral Glucose Tolerance Testing (OGTT), and Fasting Blood Draws and the core has a fully equipped metabolic kitchen and gym that can be rented for studies, meetings, exercise analyses, etc. All scans and analyses are run by experienced technicians in a quality-controlled environment.

Health Sciences Campus
Diabetes & Obesity Research Institute
2250 Alcazar Street, CSC200
Los Angeles, CA 90034
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Diabetes and Obesity Research Institute (DORI) Metabolic Assay Core

The Metabolic Assay Core provides assay services to investigators of the USC Diabetes and Obesity Research Institute (DORI), and non-DORI investigators. Services include: assistance in the measurement of hormones, cytokines, lipids and carbohydrates in human and animal biologic fluids. Equipment includes: an ELISA plate reader, YSI glucose analyzer, and Luminex technology.

Health Sciences Campus
Diabetes & Obesity Research Institute
2250 Alcazar Street, CSC123A
Los Angeles, CA 90033
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Good Manufacturing Practice Core

The Good Manufacturing Practice (GMP) Core, is located at the Saban Research Institute at CHLA. Services include: the manufacture of therapeutic grade cell-based products under GMP conditions for use in clinical trials.

Children’s Hospital Los Angeles, CHLA
Smith Research Tower
4546 Sunset Blvd., Rm 106, MS#64
Los Angeles, CA 90027
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Immune Monitoring Core

The Immune Monitoring Core offers advice, technical support and equipment for all immune monitoring needs. Equipment and services include: technical assistance for performance and/or analysis of ELISPOT, flow cytometry, radioisotope-based proliferation and cytotoxicity, multiplexing ELISA, and molecular-based quantitative PCR assays. The lab is equipped for controlled rate freezing and storage of cryopreserved peripheral blood cells, tissue culture facilities and has a 96-well plate ELISPOT reader. Assays and technical assistance are also available to support translational projects that utilize in vitro and in vivo animal models.

Health Sciences Campus
Harlyne J. Norris Cancer Research Tower
1450 Biggy Street, Room 7517
Los Angeles, CA 90033
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PharmacoAnalytical Core

The USC/Norris Core Pharmaco-Analytical Laboratory develops, validates and performs qualitative and quantitative drug assays and their metabolites in various biological matrices. Equipment and services include: high performance liquid chromatography (HPLC) using conventional UV/visible and fluorescence detection and liquid chromatograph mass spectrometry (LC-MS). The core also provides sample acquisition/storage, GC/MS and pharmacokinetic analysis.

Health Sciences Campus
USC Norris Comprehensive Cancer Center
1985 Zonal Avenue
Los Angeles, CA 90089
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Translational Pathology Facility – Slides & Soft Tissue

The Norris Cancer Center Translational Pathology Core provides normal and tumor tissue specimens for laboratory-based, epidemiologic and clinical studies conducted by Cancer Center investigators. Services include: adult and pediatric normal and tumor tissue specimens, and population-based, fixed tissue specimens.

Health Sciences Campus
Norris Comprehensive Cancer Center
1441 Eastlake Ave.
Los Angeles, CA 90089
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Translational Research Laboratory

The USC School of Pharmacy Translational Research Laboratory provides USC researchers with access to lab resources and technical guidance to promote translational research. Equipment includes: a Real-Time PCR and suspension array system, flow cytometers, bioimagers, extracellular flux analyzers, microplate readers, spectrofluorometers, automated electrophoresis systems, separation systems, multilabel readers, liquid scintillation and luminescence counters, and microplate luminometer with injectors.

Health Sciences Campus
Pharmaceutical Sciences Center
1985 Zonal Avenue, PSC406
Los Angeles, CA 90033
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