University of Southern California


PAR-17-276: NIH StrokeNet Regional Coordinating Stroke Centers

Slots:                                                     1

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        30 days prior to application due date                    

External Deadline:                          September 25, 2017, 5pm PDT

Award Information:                        Type:  Cooperative Agreement

Estimated Number of Awards: 25

Anticipated Amount: $200,000 per year for up to 5 years.

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:

Materials to submit:

 Link to Award:                        

Who May Serve as PI:                   

Awards for a NCC and a RCC may be made to the same institution.  However, it is preferable that the NCC and the RCC grant at a given institution be awarded to two PDs/PIs, to ensure that the NCC activities as well as the local RCC activities receive full attention.

A RCC may be from a single institution or may include geographically or organizationally linked partners or satellite sites, such as other academic centers and/or private and community hospitals and clinics as needed to fulfill the research requirements.


The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite currently awarded NIH StrokeNet centers and potential new stroke centers to participate as a Regional Coordinating Stroke Center (RCC) in the NIH StrokeNet Stroke Trials Network.  The goal of this existing network is to develop and conduct high-quality, multi-site Phase 1/2 and Phase 3 clinical trials focused on key interventions in stroke prevention, treatment, and recovery.  The network will consider the breadth of cerebrovascular disease beginning with patients identified with acute stroke through stroke rehabilitation and secondary stroke prevention for pediatric and adult patients.

The aims of the network are to harness multidisciplinary stroke expertise to collaboratively and efficiently conduct exploratory NINDS-sponsored Phase 1/2 clinical trials for stroke interventions with the goal to quickly move potential treatments into larger, confirmatory Phase 3 trials.  In addition, the network may perform biomarker validation studies that are immediately preparatory to clinical trial(s).  Collaboration with international consortia will facilitate the execution of the larger, Phase 3 definitive trials.  Together with the larger U.S. and the international stroke research community, stroke patients, and stroke-related nonprofit associations, the investigators at the RCC’s will work to design and execute the most clinically impactful stroke research.

Study execution and performance will be monitored by the NINDS and the National Clinical Coordinating (NCC) and National Data Management (NDMC) Centers to ensure that all eligible stroke patients are considered for NINDS-funded trials.

The NINDS intends that the NIH StrokeNet will be the primary and first-line infrastructure involved in implementing all multi-site stroke trials submitted to the NINDS.

Visit our Institutionally Limited Submission webpage for updates and other announcements.