RFA-DK-18-017: Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R01- Clinical Trial Optional)
Internal Deadline: Friday, October 19, 2018, 12pm PT
LOI: January 21, 2019
External Deadline: February 21, 2019 by 5:00 PM local time of applicant organization.
Award Information: Type: Grant
Estimated Number of Awards: NIDDK intends to commit up to $1,000,000 in FY 2019 to fund up to 3 awards.
Anticipated Amount: Application budgets are limited to $200,000 direct costs per year.
Submission Process: PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants
Materials to submit:
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
- CV – (5 pages maximum)
Who May Serve as PI: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC), in collaboration with the International IBD Genetics Consortium, has identified about 200 susceptibility loci for IBD. The IBDGC has recently been awarded renewed funding to identify causal genes and genetic variants within these loci, and to elucidate the mechanisms through which they contribute to the pathophysiology of IBD. However, the IBDGC’s current resources permit them to explore the functions of only a limited set of genes within a limited set of physiological domains. The purpose of this Funding Opportunity Announcement (FOA) is to expand the number of genes and range of IBD-related phenotypes and physiological domains under study by means of collaborations of the IBDGC with investigators with expertise complementary to that of their own members. Proposed studies must not duplicate studies either ongoing or already completed by the IBDGC. Multi-site clinical trials will not be considered responsive to this FOA.
Activities appropriate for ancillary studies include the following, as well as many others not mentioned in this list:
- Genetic analysis of IBD-related clinical and biological phenotypes in domains not previously investigated (e.g., intestinal remodeling and healing, enteric nervous system),
- Epigenomic, transcriptomic, proteomic, and metabolomic analyses of relevant tissue samples from recruited subjects, and systems biology analyses of the resulting data,
- Analyses of the composition and activities of the intestinal microbiome of recruited subjects,
- Screening of candidate genes and genetic variants in gut barrier, mucosal immune, and other physiological domains, using cultured cells, organoids, Drosophila, zebrafish, mice, and other assay platforms,
- Analyses of the relationships among host genetic variation, intestinal microbiome composition and activity, and variation in the presentation, severity, natural history, and response to treatment of IBD,
- Elucidation of regulatory interactions between DNA sites within the known IBD susceptibility loci and other genes, regardless of their genomic location, or
- Reanalysis of existing data with novel analytic approaches to identify previously unknown susceptibility loci.
Visit our Institutionally Limited Submission webpage for updates and other announcements.