RFA-GM-17-003: Centers for HIV/AIDS-Related Structural Biology (P50)
LOI: December 9, 2016, 5pm
Internal Deadline: September 16, 2016, 5pm
External Deadline: January 9, 2017, 5pm
Estimated Number of Awards: 4 – 5
Anticipated Amount: Application budgets are limited for direct costs including equipment and Collaborative Development Program funds up to 3.2 million dollars per year.
Cost Sharing: This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Submission Process: PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants
Materials to submit:
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt.).
- CV – (5 pages maximum)
Who May Serve as PI: Standard NIH requirements.
The goal of this announcement is to attract the best scientists in relevant fields to attack the problem of characterizing HIV-related macromolecular complexes. Hence the application should focus on the specific problems to be solved:
- approaches to be used
- identification of potential bottlenecks
- a plan for outreach and collaboration to the wider HIV biology community
- a workable management plan along with milestones
- the commitment and past experience of the investigators.
The research being proposed is expected to push the boundaries of what is feasible. As such, it is recognized that aspects of the plan necessarily will be of high risk.
Protein/protein complexes, both among the viral proteins, as in the structures of the virion, and between viral and host proteins, have been the focus of most prior efforts. This should continue, although a greater emphasis should be placed upon components of the virus and/or host for which a sufficiently complete structure has yet to be determined, rather than for single proteins such as reverse transcriptase and protease for which a wealth of detailed information is already available. Restriction factor targets are of particular interest, especially factors that contribute to the establishment or maintenance of viral latency and thus may represent potential therapeutic targets to effect a cure. With this re-issued FOA we would once again strongly encourage investigation into poorly characterized categories of complexes, including RNA, nucleic acid/protein, and protein/membrane interactions. For all the potential molecules and complexes integration of structure with validation strategies, including computational, biochemical, and systems biology/interactome analyses, is essential to understanding their biological functions.
Visit our Institutionally Limited Submission webpage for updates and other announcements.