Paul G. Allen Family Foundation – Allen Distinguished Investigators (ADI) Program Life Science Focus: Alzheimer’s Disease
Internal Deadline: October 27, 2014
External Deadline: January 30, 2015
Award Information: We expect to fund between 5 and 7 projects with a total funding of $1M-$1.5M, for each project, spanning a 3-year period. The Paul G. Allen Family Foundation has a 0% indirect cost policy. 2015 ADI Life Science awards have an expected combined total of $7.5M. Funding is intended to provide a sustainable funding stream for one or more investigators allowing them sufficient time to investigate big questions in-depth using risky, novel approaches.
Submission Process: Please note the change in application submission process:
PIs must submit their application utilizing the Office of Research’s new Application Portal: http://uscapplicationportal.weebly.com/
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt.).
- CV – (4 pages maximum)
Link to Award: 2015 ADI Life Science RFP-Alzheimers
Purpose: The Allen Distinguished Investigator (ADI) Program seeks to fund a select group of investigators to pursue new, pioneering research that collectively ‘moves the needle’ towards answering broad scientific questions. The most promising proposals will incorporate novel, creative, and ambitious approaches. For this reason, the program is especially interested in proposals that are unlikely to receive funding from traditional government sources.
We seek proposals whose focus would provide insights into the basic biological foundations of Alzheimer’s disease, with an emphasis on cellular biology.
Alzheimer’s disease is the most common type of dementia, with an estimated 5.2 million Americans suffering from Alzheimer’s in 2014. While there has been a wealth of knowledge gained in previous years, many questions remain about the precise biological changes that occur prior to and at the earliest stages of disease onset, basic understanding of disease progression and resistance, and how to prevent or delay Alzheimer’s disease onset.
We are seeking revolutionary new ideas to push the field in new directions or even to invent new fields of research, with an emphasis on the cellular biology on Alzheimer’s disease. This call is limited to interdisciplinary teams that include researchers in the field of Alzheimer’s disease paired with researchers in other fields (e.g. lipid biology, immunology, cerebro/vascular biology, bioenergetics, biostatistics, biomedical engineers, etc.).
Lines of Inquiry include (but are not limited to):
- The interplay/relationship between contributors to Alzheimer’s pathology. This may include some combination of protein pathologies, mitochondrial dysfunction, lipid biology, immune system, trafficking, vascular biology, etc.
- Consequences of transmission and spread of Alzheimer’s Disease pathology
- Investigation into the APOE-Amyloid-Tau interaction and roles in disease progression
- Upstream contributors that lead to downstream proteinopathies, oxidative stress, etc.
- Investigation into why some cell types more vulnerable/resistant than others; bolstering the protective ability of neurons
- Development of new cellular biology methods or techniques that will change or enhance capabilities in Alzheimer’s Disease research