PAR-15-316: Limited Competition for the Renewal of the National Cell Repository of Alzheimer’s Disease (NCRAD) (U24)
LOI: December 25, 2015
Internal Deadline: October 16, 2015; 5pm
External Deadline: January 25, 2016
Award Information: Type: Cooperative Agreement
Estimated Number of Awards: 1
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. NIA anticipates making 1 award.
Direct costs should not exceed $900,000 per year.
Cost Sharing: This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Submission Process: PIs must submit their application utilizing the Office of Research’s Application Portal: https://app.wizehive.com/webform/USCgrants
Materials to submit:
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt.).
- CV – (5 pages maximum)
Link to Award: http://grants.nih.gov/grants/guide/pa-files/PAR-15-316.html
Who May Serve as PI: Standard NIH eligibility requirements.
The National Institute on Aging (NIA) requests submission of a Renewal application for a limited
competition for the National Cell Repository for Alzheimer’s Disease (NCRAD). In the next 5 years NCRAD should continue to work toward:
- Being a state-of-the-art sample repository for DNA, cell lines, plasma, serum, RNA, brain tissue, cerebrospinal fluid and peripheral blood mononuclear cells or fibroblasts that could be used to produce IPSCs;
- Providing overall project management of research and resource goals, the ability to receive and organize previously collected biosamples and new biospecimen collections when approved by NCRAD Executive Committee (NEC), and plans for working with a range of stakeholders including government, academic scientists, industry, and data-management experts such as National Alzheimer’s Coordinating Center (NACC) and National Institutes on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADs);
- Providing scientific and laboratory expertise. This will require the skills and flexibility to apply cutting-edge science to the development and use of biospecimen protocols and QA/QC assays. It will require coordination of the receipt, processing, storage, and distribution of biospecimens from a variety of projects;
- Having the ability to link clinical data with biosamples. Projects supported by NCRAD will include both academic and industry-based research. Data sharing and protocol standardization is expected to play a significant role in the success of this as a community research resource. A user-friendly, query-based website is an essential component of the overall activity.
- It is expected in the next five-year funding period that NCRAD will expand its scope to ensure that the NIA will have a central biospecimen repository that will meet the needs of genetic research on Alzheimer’s disease and related neurodegenerative diseases, such as Frontotemporal Disorders, Lewy Body disorders and Down Syndrome. NCRAD should be a state-of-the-art central biospecimen repository for samples (DNA, cell lines, plasma, serum, RNA, brain tissue) collected by other NIA-funded studies. NCRAD will distribute data and biospecimens to qualified investigators for use in research studies following government guidelines and regulations.
Visit our Institutionally Limited Submission webpage for updates and other announcements.