University of Southern California


PAR-17-238: Developmental Centers for AIDS Research (P30)

Slots:                                                     1                             

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        30 days prior to the application due date                              

External Deadline:                          August 17, 2019, 5pm PDT

Award Information:                        Type:  Grant

Estimated Number of Awards: The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Anticipated Amount: A base of up to $750,000 total costs per center per year will be awarded. The total amount awarded will depend on the applicant institutions’ NIH HIV/AIDS-funded research base.

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:

Materials to submit:

Link to Award:                        

Who May Serve as PI:                   

NIH AIDS Funded Research Base (FRB)

Institutions/Organizations with a HIV/AIDS FRB of $10M annually (minimum) are eligible for a CFAR award.  Amounts in excess of $10M will result in a larger base award.  The NIH HIV/AIDS FRB is defined as the amount of Total Cost funding from NIH for one fiscal year (October 1 to September 30) preceding the calendar year of application submission.  CFAR applicants must maintain the required minimum FRB during the year of submission in order to be funded at the requested amount, and applicants eligible for larger base funding must maintain that minimum level in order to qualify for subsequent funding at that level.  See the RFA for more specific details.

The FRB includes NIH peer-reviewed HIV/AIDS research grants, program projects, and cooperative agreements utilizing the following mechanisms only:  DP1, DP2, P01, P50 (only the NIGMS Specialized Centers for HIV/AIDS-Related Structural Biology), R00, R01, R03, R15, R21, R24, R33, R34, R35, R37, R56, R61, SC1, SC2, SC3, U01, U10, U19, U24, UH2, UH3, UG3, and K series awards. On a case-by-case basis, the following mechanisms will be considered based on whether or not the award involves primarily research activity:  KL1, KL2, N01, PM1, U54, UG1, UM1, UM2 and RC series grants.  Excluded from the NIH AIDS FRB are all funds from any source other than NIH.  Additionally, only the amount budgeted directly to an applicant institution(s) will be included for grants over $5M in the FRB.

Multi-institutional CFAR applications may combine the NIH HIV/AIDS-funded research of all the investigators at the institutions participating in the proposed CFAR to meet the NIH AIDS-FRB eligibility.  A CFAR applicant cannot use the FRB of an institution that is already part of another CFAR or D-CFAR.  CFARs that use a distant institution for a core facility may not use the Funded Research of that institution if they are not including all of the NIH AIDS investigators at that institution as part of the CFAR. The NIH AIDS FRB is compiled from the NIH Office of AIDS Research and can be requested by the applicant institution to determine eligibility.

No institution may have more than one CFAR or D-CFAR award concurrently.  An institution that is part of a multi-institutional CFAR or D-CFAR application or award may not be listed as a multi-institutional participant in a CFAR application.  Independent campuses that are part of a large multiple city university are considered to be separate institutions, and each may submit one application.

In some cases two or more institutions that can demonstrate a credible plan for collaborative research networks using CFAR cores may wish to submit an application for a single CFAR award.  A multi-institutional CFAR application must designate a lead institution that will receive the award, should demonstrate sharing in leadership positions, and provide details of agreements regarding coordination and support of cores and activities at other participating institutions.

With appropriate justification, CFAR awards may support a core at an institution that is not part of the CFAR, including a primate facility or a foreign institution that provides a unique resource such as a clinical and/or laboratory site.



Developmental Centers for AIDS Research (D-CFARs) provide support for research and administrative infrastructure, and translational HIV/AIDS research activities at institutions that receive significant HIV/AIDS funding from NIH Institutes or Centers.  The purpose of the D-CFAR is to provide support for applicants ultimately seeking a standard CFAR. A D-CFAR will allow the applicant to develop collaborations, to experiment with core facilities that may be important to support HIV/AIDS investigators at the institution, and to build and strengthen any deficiencies that might adversely affect an application for a standard CFAR award, which could ultimately lead to the development of a competitive standard CFAR application.  The emphasis expected in a D-CFAR application will be the identification and clear description of gaps or deficiencies that would hinder development of a competitive CFAR application, and Core facilities that would reduce or eliminate these gaps. D-CFARs are intended to promote NIH HIV/AIDS research efforts at the D-CFAR institution(s).  The proposed D-CFAR priorities should align with the NIH HIV/AIDS priority topics of research for support using AIDS-designated funds (NOT-OD-15-137).

The Centers for AIDS Research program was established in 1988 and renewed through 2017.  D-CFARs were incorporated into the CFAR Program in 2000.  The mission of the CFAR program and mechanisms for achieving the mission were developed by the CFAR Directors ( ).  D-CFARs can accomplish this mission through the following:

Expected characteristics include:

  1. Added value.
    1. Developmental Core awards resulting in collaborations, publications, or successful major research grants, especially among early career investigators and investigators new to the field of HIV/AIDS
    2. Evidence of an increase in multidisciplinary research and publications
    3. Evidence of D-CFAR enhancement and support of existing programs at the award institution
    4. Research activities focused on prevention, treatment and implementation science questions in marginalized and hard-to-reach populations
    5. Commitment from the institution for support of D-CFAR activities
    6. Mentoring early career investigators in the HIV/AIDS research field and facilitating the transition to independence
    7. Promoting and supporting new collaborations designed to move the HIV/AIDS field forward through D-CFAR-sponsored meetings and activities
    8. Increase in percentage of NIH funded HIV researchers supported by the D-CFAR
  2. Scientific and fiscal flexibility.
  3. NIH-funded HIV/AIDS investigators at the applicant institutions.
  4. Collaborations with community groups, organizations, and other institutions.


The overall structure of the CFAR is designed to support the HIV/AIDS researchers at the applicant institution in the conduct of their research projects, interact with a variety of organizations to promote collaborations that serve the applicant organization, and create linkages for promoting additional HIV/AIDS research in key areas identified by the community.


Cores and Core services provide support of specific functions that facilitate HIV/AIDS research at the CFAR institution, therefore, Cores must specifically target HIV/AIDS research. (e.g. Administrative, Developmental, Basic Science, Clinical Science, etc.)

Visit our Institutionally Limited Submission webpage for updates and other announcements.