University of Southern California

Research

PAR-19-114: Non-human Primates Facilities to Support HIV/AIDS-related Research (C06 Clinical Trial Not Allowed)

Slots:                                                     Only one application per institution (identified by NIH IPF number) is allowed.                

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        February 1, 2019              

External Deadline:                          March 6, 2019, 5pm PT

Award Information:                        Type: Grant

Estimated Number of Awards: 2-4

Anticipated Amount: $3,000,000 per award.

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants

Materials to submit:

Link to Award:                                   https://grants.nih.gov/grants/guide/pa-files/PAR-19-114.html

Who May Serve as PI:                    The PD/PI should hold appropriate stature within the institutional administration structure and non-human primate HIV/AIDS-related research community to be able to oversee various facets of the entire project.

Purpose:

This Funding Opportunity Announcement (FOA) invites applications from qualified research institutions to seek funds to modernize and/or expand non-human primate (NHP) facilities. These NHP facilities must support HIV/AIDS-related research aligned with the NIH-established priorities for HIV/AIDS research. Requests for improvements of animal housing infrastructure or related on-site space dedicated to animal-based research are encouraged. Any request must be justified by current and anticipated future research needs.

The scope of individual improvement projects will vary and depend on the currently-available infrastructure at the applicant institution, as well as its present and anticipated HIV/AIDS-related research needs. Any request must be justified by research-related needs for the care and maintenance of animals or for research-related activities directly associated with the NHP facility. Any project, when completed, should provide long-term benefits to the operations and uses of the facility. Consequently, the applicant institution should demonstrate future-looking commitments towards the NHP facility and HIV/AIDS-related research therein, by attaching in a letter of support to the application from a high-ranking institutional official.

An applicant may request funds to modernize animal housing, corrals, and other animal holding space. A growing demand for animals may call for an expansion of such areas. Similarly, various functions that assist in caring for and maintaining colonies may require additional specialized structures, including cage washing, high containment space, and storage. Such requests should make a connection between the current facility’s capacity and the number / types of animals required by NIH-funded research projects and other research projects which rely on the facility. Projects to improve areas supporting activities related to the functioning of the facility, as necropsy rooms or incinerator space, are also relevant to this FOA.

An applicant may request modernization of non-human primate (NHP) facilities dedicated to on-site HIV/AIDS-related research. Examples include barrier ultraclean rooms or surgical suites. The demand for such space should be connected to current unmet needs and anticipated future use projections. Similarly, a specially designed area to house a tissue repository with sample preparation and designated processing space is another relevant example.

Various factors are typically considered when planning for and modernizing the infrastructure of facilities. For applications submitted to this FOA, it is expected that each project will implement the best engineering solutions and modern technologies to ensure animal welfare, high-quality animal care, and enable cutting-edge research activities. All projects must be justified by their relevance to the NIH-established HIV/AIDS research priorities. These priorities will drive the requests for the implementation of specific original engineering designs and leading-edge technological solutions. The proposed infrastructure improvements should offer long-term benefits for the conduct and advancement of HIV/AIDS-related research for a broad research community.

Applicants may request funds for costs of design and implementation of the project. Specifically, architectural and engineering design fees, contingency fees, construction and fixed equipment costs, and commissioning costs of the facility are allowed – compare the Funding Restrictions section for further details of allowable and non-allowable costs. Applicants are encouraged to follow sustainable design principles and to use green technologies where appropriate and practical.

Requests for regular maintenance, replacement of aging or failing equipment, and other routine repairs are not appropriate for this FOA, and such requests will not be supported.

The project should be consistent with the following criteria and documentation requirements:

    • The project is essential to the support of high priority HIV/AIDS-related research activities.
    • The facility must have a useful life consistent with program purposes, including the time to construct and complete the project, plus 20 years of use following occupancy; and
    • The building must be architecturally and structurally suitable for conversion to the type of research space required.
    • If the space is rented, evidence must be provided that the terms of the lease and expected subsequent use of the facility are consistent with the proposed project. Specifically, a signed document from the building owner must be provided, detailing that the terms of the lease agreement and subsequent use of the facility will comply with the 20-year term of the Notice of Federal Interest (NFI) requirement following the occupancy of the facility. A statement of agreement by the owner of the space must be included at the time of application submission. These documents will be verified if/when the application is considered for funding.
    • If the project will affect a site listed (or eligible for inclusion) in the National Register of Historic Places, the requirements specified in “Preservation of Cultural and Historic Resources” must be followed.

Visit our Institutionally Limited Submission webpage for updates and other announcements.