University of Southern California


PAR-19-177: High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)

***Not a limited submission***

Internal Deadline:                          Contact the Office of Research if interested. Only applicable to PIs requesting cost share from the Provost:  Those not seeking cost share should apply directly to the NIH 

LOI:                                                        N/A       

External Deadline:                          May 31, 2019, by 5:00 PM local time at the applicant organization. All types of applications allowed for this funding opportunity are due on this date.

Award Information:                        Type:  Grant

Estimated Number of Awards: ORIP intends to commit about $30 million in FY 2020 to fund an estimated 25 awards.

Anticipated Amount:
Applications will be accepted that request a single, commercially available instrument or integrated system. The minimum award is $600,001 of direct costs. There is no upper limit on the cost of the instrument, but the maximum award is $2,000,000 of direct costs. Since the cost of the various instruments will vary, it is anticipated that the size of the award will also vary. S10 awards do not allow indirect costs.

It is expected that applicants will employ the most economical approaches, including securing academic discounts, to formulate a cost-effective budget while meeting users’ scientific needs.

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:


Materials to submit:

Link to Award:                        

Who May Serve as PI:                     The PD/PI chosen for this application should have documented (in the biographical sketch) technical expertise directly related to the type of the chosen instrument. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument. The PD/PI may be a core director, tenured, or non-tenured faculty member of the applicant organization. The PD/PI must be affiliated with the applicant organization and must be registered on eRA Commons.

Multiple PDs/PIs are not allowed under the S10 mechanism.


The purpose of this funding opportunity is to continue the High-End Instrumentation (HEI) Grant Program administered by ORIP. The objective of the Program is to make available to institutions expensive research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational or clinical areas of biomedical/behavioral research. The HEI Program provides funds to purchase or upgrade a single item of expensive, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component could provide. The components must be dedicated to the system and not used independently.

Types of supported instruments include, but are not limited to: X-ray diffractometers, mass and nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers. Applications for “stand alone” computer systems (supercomputers, computer clusters and data storage systems) will only be considered if the instrument is solely dedicated to the research needs of NIH-supported investigators.

To facilitate the introduction of advanced cutting-edge instrumentation technologies providing new research capabilities to the biomedical field, a risk-return trade-off is allowed when certain classes of instruments or integrated systems are requested. Accordingly, the HEI program supports the acquisition of unique instruments or integrated systems developed by reliable commercial vendors, provided the instruments or all components of integrated systems are guaranteed by the manufacturer’s one-year warranty. Due to the novelty of the technologies and the uniqueness of their implementation, specialized and technologically savvy groups of investigators will be qualified to lead the adoption of such instruments for biomedical research and the development of innovative biomedical applications. Therefore, if such novel instrument is requested, the applicant should demonstrate special technical expertise, merging physical and biological sciences. For integrated systems, the applicant must provide a detailed description about how the system will be put together and about technical expertise of the individual(s) who will be responsible for assembling of the system. The applicant must also provide a detailed description of training for the investigators listed in the application about the use of the novel technology to advance their research.

Visit our Institutionally Limited Submission webpage for updates and other announcements.