University of Southern California


PAR-20-106: Center for AIDS Research (P30 Clinical Trial Not Allowed)

Slots:                                                     1

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        June 29, 2020

External Deadline:                          July 28, 2020

Award Information:                        Type: Grant

Estimated Number of Awards: The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Anticipated Amount: A base of up to $3,000,000 total costs per center per year will be awarded. The total amount awarded will depend on the applicant institutions’ NIH HIV/AIDS-funded research base.   The scope of the proposed project should determine the project period. The maximum project period is 5 years.                  

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:

Materials to submit:

Link to Award:                        

Who May Serve as PI:                    Standard NIH eligibility requirements.


The Centers for AIDS Research program was established in 1988 and renewed through 2021.  The mission of the CFAR program and mechanisms for achieving the mission were developed by the CFAR Directors ( The CFAR program accomplishes this mission by:

    • Providing scientific leadership and institutional infrastructure dedicated to HIV/AIDS research
    • Promoting development of sustainable multidisciplinary HIV/AIDS research programs at each CFAR institution, and enhancing synergies with additional non-CFAR partner institutions, including minority institutions, and state and local health departments
    • Stimulating scientific collaboration in interdisciplinary and translational research, through facilitating research collaborations within and among CFARs, and supporting HIV/AIDS research networks
    • Supporting basic, translational, implementation and health policy research to facilitate application of research findings to HIV/AIDS prevention and care
    • Strengthening capacity for HIV/AIDS research through international collaborations to efficiently and effectively answer important questions related to the global HIV/AIDS epidemic
    • Fostering scientific communication, promoting knowledge of research findings and disseminating important research discoveries to scientific and lay communities
    • Sponsoring HIV/AIDS-related training and education as well as providing opportunities for career development
    • Developing the next generation of scientific leaders in HIV/AIDS research through focused mentoring, career development and funding support to early career investigators
    • Engaging with the NIH and affected communities to prioritize and focus HIV/AIDS research
    • Facilitating technology transfer and development through promotion of scientific interactions between CFARs
    • Supporting research on prevention and treatment of HIV infection in underserved domestic populations and those who experience health disparities, especially in communities at high risk for HIV infection
    • Leveraging additional HIV/AIDS funding from CFAR host institutions and through philanthropy
    • Coordinating responses to emerging NIH research priorities
  1. Expected characteristics of all CFARs include:
    • Added value
    • Scientific and fiscal flexibility
    • NIH-funded HIV/AIDS investigators at the applicant institutions.
    • Collaborations with community groups, organizations, and other institutions.

NIH HIV/AIDS Funded Research Base (FRB) Requirement:

Institutions/Organizations with a HIV/AIDS FRB of $10M annually (minimum) are eligible to apply for a CFAR. Amounts in excess of $10M will result in a larger base award.  The NIH HIV/AIDS FRB is defined as the amount of Total Cost funding from NIH for one fiscal year (October 1 to September 30) preceding the calendar year of application submission.  CFAR applicants must maintain the required minimum FRB during the year of submission in order to be funded at the requested amount, and applicants eligible for larger base funding must maintain that minimum level in order to qualify for subsequent funding at that level.  For example, if an applicant has an FRB in 2018 that makes them eligible for $2.25M in funding, they must maintain the required FRB for funding at the $2.25M funding level in 2019 in order to be funded at that level.  This applies only to competing applications. The NIH HIV/AIDS FRB is compiled from data provided by the NIH Office of AIDS Research to determine eligibility. Applicants can request the FRB from NIAID.

CFARs qualify for three tiers of funding based on the FRB for the institution.

Tier 1: For institutions with a minimum of $10M, but less than $40M FRB, a CFAR award will use a base of $1.5M total cost in the first year of the competing segment.

Tier 2: For institutions with a minimum of $40M but less than $80M FRB, a CFAR award will use a base of $2.25M total cost in the first year of the competing segment.

Tier 3: For institutions with a minimum of $80M FRB, a CFAR award will use a base of $3M total cost in the first year of the competing segment.

The FRB includes NIH peer-reviewed HIV/AIDS research grants, program projects, and cooperative agreements utilizing the following mechanisms only:  DP1, DP2, DP5, R00, R01, R03, R15, R21, R24, R33, R34, R35, R36, R37, R56, R61, RF1, SC1, SC2, SC3, U01, U10, U19, U24, U34, UH2, UH3, UG3, and K series awards. On a case-by-case basis, the following mechanisms will be considered based on whether or not the award involves primarily research activity:  KL1, KL2, N01, P01, P50, PM1, U54, UG1, UM1, UM2 and RC series grants.  Excluded from the NIH HIV/AIDS FRB are all funds from any source other than NIH.  Additionally, only the amount budgeted directly to an applicant institution(s) will be included for grants over $5M in the FRB.

Visit our Institutionally Limited Submission webpage for updates and other announcements.

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