University of Southern California


RFA-AI-19-068: Immune Tolerance Network (UM1 Clinical Trial Required)

Slots:                                                     1

Internal Deadline:                           Monday, January 13, 2020, noon PT

LOI:                                                        February 3, 2020

External Deadline:                          March 3, 2020

Award Information:                        Type: Cooperative Agreement

Estimated Number of Awards: 1

Anticipated Amount: $27 million in FY2021.  

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:

Materials to submit:

Link to Award:                        

Who May Serve as PI:                    Standard NIH eligibility requirements


The purpose of this FOA is to solicit applications for the Immune Tolerance Network. The major objective of the Network is to develop tolerogenic approaches for the treatment of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out by the Network includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approaches for the induction and maintenance of immune tolerance in humans; 2) the design and conduct of mechanistic studies and the development of tolerance assays as integral components of the clinical trials undertaken; and establishment of biospecimen repositories 3) the provision of services on data management in collaboration with other resources provided by NIAID, bioinformatics analysis, and data sharing in a secure computing environment to support clinical trials and mechanistic studies. The Network may also support limited product development and nonclinical studies (e.g., toxicology, pharmacology, pharmacokinetics, etc.) essential for the subsequent evaluation of promising tolerance induction approaches in humans.

Budgetary Requirements:           This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

Visit our Institutionally Limited Submission webpage for updates and other announcements.