RFA-AR-19-002, NIAMS Musculoskeletal Biology and Medicine Resource-based Centers (P30 – Clinical Trial Not Allowed)
Internal Deadline: Contact the Office of Research if interested.
LOI: 30 days prior to the application due date
External Deadline: June 11, 2018, by 5:00 PM local time
Award Information: Type: Grant
Estimated Number of Awards: maximum of four awards
Anticipated Amount: up to $2.0 million total
Submission Process: PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants
Materials to submit:
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
- CV – (5 pages maximum)
Who May Serve as PI: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
The NIAMS requests applications for the NIAMS Resource-based Centers Program (P30) to provide critical research infrastructure, shared facilities, services, and resources to groups of investigators conducting research on musculoskeletal biology and medicine, with the broad overall goal of accelerating, enriching, and enhancing the effectiveness of ongoing basic, translational, and clinical research and promoting new research on musculoskeletal biology and medicine within the NIAMS mission. The Centers could potentially facilitate projects in many areas of musculoskeletal biology and medicine, including the muscles, skeleton, cartilage, and other connective tissues such as tendon and ligament. Skeleton (bone) and cartilage are connective tissues, and cartilage will include intervertebral disk (IVD) and meniscus. Key public health problems addressed by this research include, but are not limited to, osteoporosis, osteoarthritis, orthopaedic disorders, and muscle diseases including muscular dystrophies.
NIAMS expects that the Resource-based Center Program will:
- Efficiently provide critical research infrastructure to advance fields within the NIAMS mission
- Include Cores that offer resources and services in addition to equipment and other infrastructure
- Serve basic, translational and/or clinical research
- Contribute and/or facilitate significant innovations in research and technology
- Facilitate expansion of research fields within the NIAMS mission
- Foster innovative exploratory projects and junior investigators
- Have flexibility to adopt and adapt to emerging needs and opportunities
Each Center must include one or more Resource Core(s). A Resource Core is a facility and/or resource shared by or providing services to multiple research community investigators, enabling them to conduct their independently-funded individual and/or collaborative research projects more efficiently and/or more effectively. The selection of Resource Cores is left up to the PD/PI, but should be justified by the needs of the research community and should be appropriate for the focus of the Center which should be within the NIAMS mission. Resource Cores may be located at multiple institutions separated geographically.
For the purpose of this FOA, examples of Resource Cores include, but are not limited to, Cores providing the following:
- A technology that lends itself to standardized procedures, automation or preparation in large batches (e.g., histology, tissue culture, biobanking, high throughput sequencing, genotyping, and other genomic, epigenomic, and microbiomic assays) or that requires complex instrumentation (e.g. electron microscopy, flow cytometry, confocal microscopy, intravital microscopy, whole animal imaging, and mass spectrometry).
- Animal preparation (including transgenic, knockout, and other forms of genetic engineering/gene editing) and care.
- Highly specialized technologies, tools, and expertise such as epidemiology, outcomes, genetics, medical informatics, bioinformatics, biostatistics, systems biology, pharmacogenomics, clinical trial design and support, regulatory affairs, etc.
- Critical infrastructure to support broad sharing of accessible pre-existing patient cohorts and registries, including appropriately-consented patient samples and associated clinical data.
Visit our Institutionally Limited Submission webpage for updates and other announcements.