University of Southern California


RFA-DE-19-002: National Dental Practice-Based Research Network: Coordinating Center (U01 Clinical Trial Required)

Slots:                                                     1             

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        June 17, 2018                    

External Deadline:                          July 17, 2018

Award Information:                        Type:  Cooperative Agreement

Estimated Number of Awards: 1

Anticipated Amount: $2,200,000

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:


Materials to submit:


Link to Award:                         

Who May Serve as PI:                    Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.


The National Institute of Dental and Craniofacial Research (NIDCR) intends to continue support for research conducted within a national Dental Practice-Based Research Network (DPBRN). The NIDCR will fund one national DPBRN Administrative and Resource Center led by a National Network Director(s) and one national DPBRN Coordinating Center, as companion awards, to support the infrastructure for and implementation of multiple observational studies and clinical trials. This funding opportunity announcement (FOA) is soliciting applications for the national DPBRN Coordinating Center; a separate companion FOA is soliciting applications for the national DPBRN Administrative and Resource Center (RFA-DE-19-001). The national DPBRN Administrative and Resource Center award will include funds to support developmental/exploratory, pilot, and/or survey studies to be conducted in the DPBRN; a future FOA will solicit applications for investigator-initiated clinical observational studies and clinical trials to be conducted in the DPBRN.

The purpose of the national DPBRN Coordinating Center is to centralize and harmonize study operations, data management, and biostatistical support to facilitate rapid development and implementation of clinical studies conducted in the national DPBRN. The main goals of the national DPBRN are to maximize efficiencies to conduct national oral health research studies in dental practices on topics of importance to practitioners and their patients, to provide evidence useful in daily patient care, and to facilitate the translation of research findings into clinical practice.

This FOA solicits applications for a single national Coordinating Center to support the national DPBRN infrastructure and the development/implementation of multiple national oral health clinical studies during an up to 7-year project period. The national DPBRN will conduct multiple prospective and/or retrospective, observational clinical studies and clinical trials with a focus on general dental practice, and will also incorporate projects of interest to dental specialists and other dental professional groups, specific dental practice types, and patient advocacy groups. The projects of interest to specific dental groups and practice types and patient advocacy groups may be addressed through public-private partnerships.

Research studies will address oral health issues of importance to dental practitioners. Studies may evaluate particular clinical approaches or evaluate the effectiveness of strategies for the prevention, management and treatment of oral diseases and conditions. While good evidence exists for many treatments used by dental practitioners to prevent and manage oral and craniofacial diseases, dissemination and implementation of this knowledge remains a challenge. Therefore, the goal of each study carried out by the national DPBRN is to strengthen the knowledge base for clinical decision-making, and the DPBRN is an ideal venue to translate research findings into practice.

Visit our Institutionally Limited Submission webpage for updates and other announcements.