University of Southern California

Research

RFA-DK-19-003, Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional)

Slots:                                                     1            

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        June 18, 2019                    

External Deadline:                          July 18, 2019, by 5:00 PM local time of applicant organization.

Award Information:                        Type:  Grant

Estimated Number of Awards:  NIDDK intends to commit up to $ 5.8M in FY 2020 to fund up to 5 awards. The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Anticipated Amount: Application budgets are limited to $750,000 direct costs per year.  Equipment costs (only allowed for first year) and indirect costs on subcontracts are not included in the $750,000 direct cost cap.  It is anticipated that the award budget will be directly correlated to the breadth, quality and relevance to Cystic Fibrosis of the research base being served by the Center.

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants

Materials to submit:

Link to Award:                                  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-003.html

Who May Serve as PI:                   

Because a Cystic Fibrosis Research Center has a large and complex administrative structure, the PD/PI must have strong leadership abilities and demonstrated proficiency in managing large, multi-component programs. In addition, the PD/PI should be a recognized leader and authority in the CF research community.  The PD/PI must be willing to participate in meetings of the CF Center Directors which are scheduled in years 1, 3 and 5 of the grant.

Research Base:  Successful CF Research and Translation Center applications require an existing program of excellence in biomedical research in Cystic Fibrosis. To justify Center support, the CF Research and Translation Center must serve a large research base of NIDDK and other NIH-funded investigators pursuing research activities in Center topic areas, as well as CF investigators with other sources of peer-reviewed support. NIDDK mission-related research should represent at least 40% of the research base. NIDDK research interests related to cystic fibrosis include mechanisms underlying the disease (excluding those associated with the specific development of lung disease), development of therapeutic approaches targeting or applicable to multiple organs, and elucidating pathophysiology and/or therapy directed at diabetes, and/or nutrition, gastrointestinal and liver complications of CF.  While additional research interests outside the NIDDK mission (e.g., pulmonary complications of CF) may also be described and these research projects may utilize Center resources, applicant institutions should be pursuing major efforts directly related to NIDDK research priorities.

Major themes should be relevant to NIDDK research interests related to cystic fibrosis which include mechanisms underlying the disease (excluding those associated with the specific development of lung disease), development of therapeutic approaches targeting or applicable to multiple organs, and elucidating pathophysiology and/or therapy directed at diabetes, and/or nutrition, gastrointestinal and liver complications of CF.  While additional research themes outside the NIDDK mission (e.g., pulmonary complications of CF) may also be described and these research projects may utilize Center resources, applicant institutions should be pursuing major themes directly related to NIDDK research priorities.

Purpose:

This Funding Opportunity Announcement (FOA) invites applications for Cystic Fibrosis (CF) Research and Translation Core Centers.  CF Research and Translation Core Centers are designed to support both basic and clinical research on Cystic Fibrosis.  CF Research and Translation Core Centers support three primary research-related activities: Research Core services; a Pilot and Feasibility program; and an Administrative Core with an enrichment program.  Core Centers provide shared resources to support research to develop and test new therapies for CF and to foster collaborations among institutions with a strong existing research base in CF.  The NIDDK currently supports seven CF Research and Translation Centers located at institutions with documented programs of research excellence in basic and clinical CF Research.  Information about the currently funded CF Research and Translation Centers may be found at:

The NIDDK CF Research and Translation Centers are part of an integrated program of research support designed to enhance multidisciplinary research in pathogenesis and treatment of cystic fibrosis and its complications.  The goal of these Cystic Fibrosis Research and Translation Core Centers is to support research to develop and test therapies for CF.  These Centers will provide resources for communication and collaboration between basic and clinical researchers. CF Research and Translation Core Centers support three primary research-related activities:(1) Research Core Services that provide shared resources to enhance the efficiency of research and foster collaborations within and among institutions with strong existing bases of research on cystic fibrosis; (2) a Pilot and Feasibility Program designed to foster the development of new investigators and to provide seed-support for innovative high-risk projects; and (3) an Administrative Core with an Enrichment Program to promote interdisciplinary interaction and educational updates for investigators.

Examples of types of biomedical core resources that would be considered responsive to this Funding Opportunity Announcement include:

    • Collection, analysis, storage and distribution of data and samples;
    • Provision of specialized tools and technologies or access to specialized expertise;
    • Development, standardization and distribution of reagents and/or protocols;
    • Recruitment of patients and coordination of patient studies;
    • Development, beta-testing and dissemination of specialty assays, methods, and services on an Institutional or national level;
    • Sharing of specialized tools, technologies and expertise among investigators.

Visit our Institutionally Limited Submission webpage for updates and other announcements.