RFA-DK-19-015 – Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Clinical Research Centers (U01 Clinical Trial Optional)
Internal Deadline: Contact the Office of Research if interested.
LOI: October 7, 2019
External Deadline: November 7, 2019, by 5:00PM local time
Award Information: Type: Cooperative Agreement
Estimated Number of Awards: NIDDK intends to commit $2,200,000 to fund up to 7 awards in FY 2020.
NIA intends to commit $100,000 to fund up to one award in FY 2020.
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Anticipated Amount: Applications budgets are limited to $450,000 direct costs per year for each Clinical Research Center. Application budgets for the PLUS Clinical Research Centers must reflect the actual needs of the proposed research each budget year.
Submission Process: PIs must submit their application as a Limited Submission through the Office of Research Application Portal: https://app.wizehive.com/webform/USCgrants
Materials to submit:
- Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
- CV – (5 pages maximum)
Who May Serve as PI: Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
The goal of this FOA is to establish the knowledge and evidence base necessary to permit future studies of prevention of LUTS in adolescent and adult women. In general, prevention research takes a multi-factorial approach to include: epidemiologic studies to identify and assess risk and protective factors; to screen and identify individuals and groups at risk; to develop and evaluate interventions designed to reduce risk; and translate and disseminate effective preventive interventions into practice. Prevention research targets the full spectrum of factors responsible for disease manifestations, to include biologic factors, individual knowledge, beliefs and behaviors, the social and physical environment and health services. There are opportunities to further define and promote healthy bladder habits through focused research, which may lead to improvements in overall health and quality of life. Ultimately this research will inform public and health care professional education efforts.
The objectives for this FOA are 1) to design and establish a longitudinal national, population-based observational cohort to determine the state of bladder health in US adolescent and adult women and to monitor changes in bladder health over time; 2) to identify risk and protective factors that may enhance bladder health and are plausible targets for future intervention studies; 3) to design and conduct additional studies (using existing literature and databases, qualitative and quantitative methodologies including pilot intervention studies) that will facilitate successful intervention studies; and 4) to develop any new measures that will be necessary to determine short and long-term impact of future intervention studies.
The goals and objectives of the PLUS Research Consortium will be complementary to two other NIDDK supported multi-center collaborative networks studying the lower urinary tract, the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) and the Multidisciplinary Approach to the study of Chronic Pelvic Pain (MAPP) Research Network. When appropriate the PLUS Research Consortium will interact and work collaboratively with these networks.
This Funding Opportunity Announcement (FOA), RFA-DK-19-015, will support up to seven Clinical Research Centers for a five-year funding period to conduct a longitudinal, observational cohort study and other studies necessary to add to the evidence base that will support future intervention studies.
Visit our Institutionally Limited Submission webpage for updates and other announcements.