University of Southern California


RFA-ES-20-006: Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional)

Slots:                                                     1

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        April 28, 2020, March 16, 2021, March 14, 2022

External Deadline:                          May 18, 2020, April 16, 2021, April 14, 2022

Award Information:                        Type: Grant

Estimated Number of Awards: 5-7

Anticipated Amount: $850,000 Direct Costs per year for new or first-time applicants; $1m Direct Costs per year for renewals.


Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:

Materials to submit:

Link to Award:                        

Who May Serve as PI:                   

To be eligible for an EHS CC award, the applicant institution must demonstrate that they have a minimum of six active NIEHS-supported research awards from four distinct PDs/PIs who are members of the proposed Center. At the time of submission of an application, the qualifying awards must have at least 1 full active year remaining.


Acceptable support includes R00, R01, R03, R21, R24, R33, R35, R43, R44, P01, P42, P50, U01, U19, U24, U2C, UG3 and or Research Career Development Awards (K-grants). Multi-component (e.g. P01, P50, or U19) awards only count as one qualifying research project (i.e., sub-components are not separately counted).


T-awards, U45, and Conference awards (R13, U13) do not count towards this requirement.  Furthermore, grants and cooperative agreements in extension periods, either with or without additional funds, as well as supplements of any kind, do not count toward this requirement.


The overall goals for the EHS CC Program are to enhance the capabilities of existing programs in environmental health sciences, assist with building programmatic and scientific capacity, lead in the development of novel research directions, recruit and groom future leaders in the field, and pioneer efforts in community engagement. The EHS CC grant provides facilities and resources to accelerate research along the spectrum from basic mechanistic and toxicological science to population and public health and dissemination. Moreover, with the release of the translational research (TR) framework for the environmental health sciences (, it is expected that an EHS CC facilitate translational research that encompasses all aspects of an EHS CC.  The TR framework is an innovative tool that incorporates the dynamic nature of environmental health research to inform and facilitate the use of scientific/public health advances across the translational spectrum to accelerate improving the health of individuals and the public.

Ultimately the EHS CC should create a structure and flexibility that allow center members with different expertise to come together to answer complex and/or emerging questions and capitalize on the latest scientific trends leading to improved strategies towards preventing environmentally-induced disorders by considering and encompassing multiple translational pathways, not just to other scientific disciplines but to the bedside, to the community, to individual behaviors and choices, and to wider public policy changes and public health practice. While the EHS CC grant provides support for core resources and facilities, it does not provide direct funding for research projects, although limited funds are provided for pilot projects.


NIEHS considers community engagement and multi-directional communication as essential activities to advance the goals and relevance of an EHS CC. Therefore, the structure of the Center should facilitate multi-directional interaction with communities and EHS CC members through the required Community Engagement Core (CEC).  In addition, EHS Cores are expected to attract established and promising investigators into environmental health research and provide opportunities for career enhancement.


To qualify for an EHS CC, the applicant institution must have a base of ongoing, independently supported, peer-reviewed research projects clearly dedicated to the study of environmental health sciences or environmental medicine, a substantial portion of which should be supported by NIEHS.  The research base must exist prior to the submission of an application and will be considered by program staff to determine eligibility.  See Section III.1 Eligible Applicants for more detailed description of EHS base support calculation.


Budgetary Requirements:           Please see solicitation as budgetary requirements vary depending on the type of core center.

Visit our Institutionally Limited Submission webpage for updates and other announcements.