University of Southern California


RFA-GM-19-002: The NIGMS Human Genetic Cell Repository (U42 – Clinical Trial Not Allowed)

Slots:                                                     1                             

Internal Deadline:                           Contact the Office of Research if interested.

LOI:                                                        N/A

External Deadline:                          July 9, 2019, 5pm

Award Information:                        Type: Cooperative Agreement

Estimated Number of Awards: 1

Anticipated Amount: $2 million

Cost Sharing:                                     N/A

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:


Materials to submit:

  • Single Page Proposal Summary (0.5” margins; single-spaced; font type: Arial, Helvetica, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 1-page limit will be excluded from review.
  • CV – (5 pages maximum)

Link to Award:                        

Who May Serve as PI:                    Standard NIH eligibility requirements.


The repository acquires cell samples from individuals affected by genetic disorders and from normal control individuals and establishes and distributes cell lines and DNA to researchers.  It also offers certain on-demand custom services related to providing cell cultures and DNA samples.  The repository is expected to stimulate research by encouraging investigators, through the easy availability of high-quality material, to try a new technique or to test a new hypothesis with human cells that could otherwise not be done due to a lack of access to an appropriate patient population.  The repository is expected to continue to facilitate research by providing high-quality, uncontaminated, well-characterized, and clinically and molecularly well-documented cell lines and high-quality DNA samples to investigators at academic, non-profit, and for-profit institutions throughout the United States and abroad.


The work to be supported by this cooperative agreement includes six separate but interrelated functions:

  1. The maintenance and distribution of the approximately 11,400 cell lines currently in the repository’s collection, the acquisition of new cell samples, and the establishment and characterization of permanent cell lines from these samples.
  2. The maintenance of the current stock of DNA samples for approximately 5,800 cell lines and the preparation, storage, and distribution of purified, high-quality DNA samples from additional selected cell lines in the repository.
  3. The provision of additional genetic services and distribution of other reagents as determined by the awardee and NIGMS staff.
  4. The enhancement and maintenance of a comprehensive computerized database providing detailed information on each cell line and DNA sample, and the provision of a Web-based electronic catalog that continues, at a minimum, to list in an easily accessible format cell lines and DNA samples and as much information about them as is currently available.
  5. The publicizing of the repository’s collections through dissemination of information by a variety of means, including publication of descriptions of the collections in relevant journals, paid advertisements, and other activities.
  6. The dissemination of biobanking best practices and knowledge through outreach and engagement with the global biobanking community.

Visit our Institutionally Limited Submission webpage for updates and other announcements.