University of Southern California


RFA-NS-19-036: HEAL Initiative: Early Phase Pain Investigation Clinical Network – Specialized Clinical Centers (U24 Clinical Trial Not Allowed)


Slots:                                                     1                             

Internal Deadline:                           Contact OOR if interested.

LOI:                                                       May 3, 2019

External Deadline:                          June 3, 2019

Award Information:                        Type: Cooperative Agreement

Estimated Number of Awards: 10

Anticipated Amount: $150,000 in direct costs for each year for 5 years

Cost Sharing:                                     N/A

Submission Process:                     PIs must submit their application as a Limited Submission through the Office of Research Application Portal:


Materials to submit:

Link to Award:                          

Who May Serve as PI:                    Standard NIH eligibility requirements.


The purpose of this funding opportunity announcement (FOA) is to invite applications for the Specialized Clinical Centers (“hubs”)of the Early Phase Pain Investigation Clinical Network (EPPIC-Net). EPPIC-Net will serve as the cornerstone of the NIH’s Helping to End Addiction Long-term (HEAL) Partnership. EPPIC-Net will harness multidisciplinary clinical, statistical, and data management expertise to provide the scientific leadership and infrastructure required to design and conduct multi-site Phase 2 clinical trials, biomarker validation studies, and deep phenotyping of patient populations to understand the biologic basis of a specific pain condition and its response to treatment. The overall goal is to accelerate development of non-addictive therapies for adult or pediatric patients with acute and/or chronic pain. Due to the enormous disease burden of low back pain (as outlined in the background), one further research objective of EPPIC-Net is to dissect the structures and mechanisms involved in chronic low back pain as well as to identify, prioritize and test new therapies targeted to these specific mechanisms.


Clinical studies may come to the network from two sources:


The responsibilities of the EPPIC-Net hubs include but are not limited to:

FYI: Awards for a hub and a Clinical Coordinating Center (CCC, RFA-NS-19-023 ) or Data Coordinating Center (DCC, RFA NS-19-024) may be made to the same institution. There must be different principal investigators leading the hub and the CCC or DCC to ensure that each activity receives full attention.

Visit our Institutionally Limited Submission webpage for updates and other announcements.