University of Southern California

Research

COVID-19 Research Resources

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COVID-19 Human Subjects Studies and Human Data Studies
COVID-19 Datasets
COVID-19 Computing Resources
COVID-19 Other Resources
COVID-19 Core Facilities
Manufacturing Masks & Face Shields
Donations of PPE

 

COVID-19 Human Subjects Studies and Human Data Studies

Investigators seeking to conduct new research involving COVID-19 biospecimens or access to patients with or at risk for COVID-19 need to submit their proposals to the IRB.

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COVID-19 Datasets

BIO COVID-19 Therapeutic Development Tracker: BIO’s Industry Analysis Team has reviewed and annotated pipeline data from BioCentury and Biomedtracker to create a granular, interactive view of the Covid-19 pipeline. The team has investigated each drug as to original inventor (company/country), mechanism of action and strategic approach, as well as de-duplicated multiple company and university programs for the same active ingredient (for example, hydroxychloroquine is counted only once). Learn more at BIO.

CDC National Center for Heath Statistics, Provisional Death Counts for Coronavirus Disease (COVID-19): The provisional counts for coronavirus disease (COVID-19) deaths are based on a current flow of mortality data in the National Vital Statistics System. Learn more at National Vital Statistics System.

CDC National Center for Heath Statistics, Laboratory-Confirmed COVID-19-Associated Hospitalizations: The Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET) conducts population-based surveillance for laboratory-confirmed COVID-19-associated hospitalizations in children (persons younger than 18 years) and adults. Learn more at COVID-19 Hospitalizations.

Coronavirus Knowledge Hub: An up-to-date source of trusted information and analysis on COVID-19 and coronaviruses. Learn more at Coronavirus Knowledge Hub.

COVID-19 Data Archive: COVID-ARC helps address the immediate need to understand the spread and impact of COVID-19 with a platform of networked and centralized archives that store, curate, visualize, and disseminate multimodal data related to the disease. The platform includes patients’ demographics, clinical evaluations, vitals, EKGs, and imaging data, such as CT, X-Ray, PET, and MRI. COVID-ARC data, together with a variety of analytic tools, are shared broadly with the world-wide scientific community. This will help maximize the potential for research progress by uniting scientists from diverse fields, including medicine, public health, and artificial intelligence. Learn more at COVID-ARC.

COVID-19 Neuro Databank/Biobank (NeuroCOVID): A new database will collect information from clinicians about COVID-19-related neurological symptoms, complications, and outcomes as well as COVID-19 effects on pre-existing neurological conditions. NeuroCOVID will be a resource of clinical information as well as biospecimens from people of all ages who have experienced neurological problems associated with SARS-CoV-2 infection. The database is supported by the NIH. Learn more at NeuroCOVID.

COVID-19 Open Research Dataset (CORD-19): In response to the COVID-19 pandemic, the Allen Institute for AI has partnered with leading research groups to prepare and distribute the COVID-19 Open Research Dataset (CORD-19), a free resource of over 29,000 scholarly articles, including over 13,000 with full text, about COVID-19 and the coronavirus family of viruses for use by the global research community. Learn more at SemanticScholar.org and Kaggle.

COVID-19 Porfolio: The iSearch COVID-19 portfolio is NIH’s comprehensive, curated source for publications related to COVID-19. This portfolio includes articles from PubMed and pre-prints from arXiv, medRxiv, bioRxiv, and ChemRxiv. It’s updated daily with the latest available data. Learn more at COVID-19 Porfolio.

COVID-19 SeroHub: COVID-19 SeroHub initially contains data from 40+ seroprevalence studies conducted in the U.S. by the CDC, NIH, state and local health departments, universities, and other sources. Studies will be added to the hub as they become available. Learn more at COVID-19 SeroHub.

Data harmonization and sharing are essential for COVID-19 research: NIA staff are collaborating with NIH colleagues to coordinate and catalogue the large number of pandemic-specific questionnaires, modules, and scales about COVID-19 experiences and impacts, and to discourage the development of one-off survey instruments. Learn more at NIH.gov.

Johns Hopkins Coronavirus Map & Resource Center: The map was first shared publicly on Jan. 22. It was developed to provide researchers, public health authorities, and the general public with a user-friendly tool to track the outbreak as it unfolds. All data collected and displayed are made freely available through a GitHub repository, along with the feature layers of the dashboard, which are now included in the ESRI Living Atlas. Learn more at coronavirus.jhu.edu.

Medical Imaging and Data Resource Center: MIDRC has launched a repository of imaging data to facilitate medical imaging research on COVID-19. The eventual repository—to include CT scans and x-rays— is planned to be to the largest open database of anonymized COVID-19 medical images, along with associated clinical data, in the world. The imaging data is a free resource for research and education communities world-wide to study, use in development of artificial intelligence (AI) and deep learning tools, and serve as a reference to enhance clinical recognition of COVID-19. Learn more at MIDRC.

NCBI SARS-CoV-2 Resources: Are you trying to keep up with the rapidly growing number of biological resources associated with the SARS-CoV-2 virus and the related disease, COVID-19? Find SARS-CoV-2-related content available at NCBI. It will help bench scientists, bioinformaticians, clinicians, and others connect with the information they need to study SARS-CoV-2 and end the COVID-19 pandemic. Learn more at NCBI SARS-CoV-2 Resources.

USC Libraries: Coronavirus (COVID-19): Resources for COVID-19 information at USC Libraries including Public Health National & International Government Coronavirus Resources for Health Professionals, Coronavirus Research Portals, and Other Coronavirus Resources for Healthcare Professionals. Learn more at libguides.usc.edu/coronavirus.

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COVID-19 Computing Resources

COVID-19 High Performance Computing Consortium: The Trump administration has unveiled a new initiative to help researchers worldwide harness a range of America’s most powerful high-performance supercomputing resources to deliberately accelerate new discoveries in the fight against COVID-19. Scientists can tap into 16 of America’s top computing systems. Learn more at COVID-19 HPC Consortium.

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COVID-19 Other Resources

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development: This report examines these vaccines and the related research effort, both traditional and forward-looking, to illustrate the advantages and disadvantages of their technologies, to denote the use of adjuvants and delivery systems in their application, and to provide a perspective on their future direction. Learn more at ACS Publications.

Against Pandemic Research Exceptionalism: Crises are no excuse for lowering scientific standards. Read this article from the American Association for the Advancement of Science.

Bioinformatics Self-learning Resources Guide: Compiled for researchers who are interested in learning how to carry out some of the most common bioinformatics tasks.  This resource provides links to previous workshops and training on their licensed commercial bioinformatics software.  It also includes links to a hand-picked list of high-quality publicly accessible bioinformatics tutorials and webinars from other institutions, focusing on open-source tools. Visit Bioinformatics Self-learning Resources Guide.

Candid: Candid has created a pop-up webpage with Funding summary, Funding opportunities, Webinars, News, Blog posts, External resources, etc to get you the information you need to do good during the novel coronavirus (COVID-19) pandemic. They invite nonprofits seeking support because of the crisis, funders who wish to learn what their peers are doing, the media, and all who wish to know more about philanthropy’s response to the pandemic to take advantage of this resource. Learn more at Philanthropic response to coronavirus (COVID-19).

Coronavirus: Research, Commentary, and News: The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19 and the coronavirus that causes it. All content is free to access. Visit sciencemag.org.

COVID-19 Testing Strategies for Colleges and Universities: States that testing programs need to be designed to match the needs of specific institutions and identifies fast, frequent testing as one useful tool to mitigate the spread of COVID-19 in a large and diverse university community. Learn more COVID-19 Testing Strategies.

Encouraging Protective Covid-19 Behaviors Among College Students uses the science of adolescent development to explore how colleges can most effectively encourage students to adopt behaviors that help prevent spread of the virus, such as mask wearing and physical distancing. Learn more at Encouraging Protective COVID-19 Behaviors among College Students.

Eric Topol’s Twitter: Eric Topol is an American cardiologist, geneticist, author, and scientist. He is the Founder and Director of the Scripps Research Translational Institute in La Jolla, California. Follow him at twitter.com/EricTopol.

Government-University-Industry Research Roundtable (GUIRR): Please join GUIRR for a conversation with Dr. Dario Gil, Director of IBM Research and co-chair of the Consortium, member of the President’s Council of Advisors on Science and Technology, and nominee to the National Science Board; and Michael Rosenfield, Vice President for Data Centric Solutions at IBM Research, who has played a leadership role in the creation and operation of the Consortium, to discuss the formation of the Consortium and the way it matches researchers to supercomputing capabilities. Learn more at COVID-19 High Performance Computing Consortium.

Interlibrary Loan and Document Delivery (IDD): COVID-19 and IDD: The USC Libraries has been actively supporting researchers during our time off campus, providing support to faculty to move their course content online and providing digital content and physical materials for their research as well. Learn more at COVID-19 and IDD about the process for requesting physical materials from the USC Libraries.

Joint Acquisition Task Force (JATF): Led by Stacy Cummings, the Principal Deputy Assistant Secretary of Defense for Acquisition — has been established to integrate DOD, HHS, DHS, and FEMA support for COVID-related requirements. JATF has created a portal where companies can propose solutions to government needs, with an initial focus on medical and pharmaceutical requirements. The landing page for the JATF is acq.osd.mil/jatf.html.

Just One Giant Lab: A “decentralized open research and innovation laboratory” that is encouraging the global scientific community to join the Open-COVID-19 Initiative, an “open source methodology to safely test for the presence of SARS-CoV-2 using tools as common as possible.” For more information, visit this FAQ from the AXA Research Fund.

Learning from Rapid Response, Innovation, and Adaptation to the COVID Crisis: Adaptations to Federal Funding and Research Regulation: Meeting Materials – Agenda – GUIRR Meeting October 2020; Gary Disbrow presentation slides; Michael Lauer presentation slides.

National Academy of Engineering (NAE) Call for COVID-19 Action Platform: NAE has created an incubator initiated in a Slack platform for the Grand Challenges Scholars Program (GCSP) and Frontiers of Engineering (FOE) communities, along with others, to collectively brainstorm on potentially innovative engineering ideas that could help ameliorate the virus itself and/or its collateral discontinuities, such as impacts on the supply chain and closure of schools. Learn more at Call for Engineering Action on the COVID-19 Crisis.

National Academies of Sciences, Engineering, and Medicine: Each year, thousands of the world’s leading experts participate in our projects, studies, and other advisory and convening activities to examine and assemble evidence-based findings to address some of society’s toughest challenges. In addition, the National Academies pursue a wide range of activities to strengthen the scientific, engineering, and medical fields and their capacity to contribute to human welfare. See recent workshops.

National Endowment for the Humanities (NEH): NEH received $75 million in supplemental funding to assist cultural institutions and humanists affected by the coronavirus as part of the $2.2 trillion CARES Act economic stabilization plan. Learn more at Funding for NEH Applicants.

National Summit on the Science and Technology of Epidemiological Modeling and Prediction – The White House Office of Science and Technology Policy (OSTP) asked the Science and Technology Policy Institute (STPI) to support the National Summit on the Science and Technology of Epidemiological Modeling and Prediction (Summit), which was held in a virtual format on November 12–13, 2020. Read the Summary Report.

Project PREPARE: The free and open Project PREPARE resource is a virtual organization to facilitate communication and collaboration among the community conducting pandemic research, supported by NSF CISE. Learn more at Project PREPARE.

Research Ethics Consultation During the Coronavirus Pandemic: There are many ways in which the COVID-19 pandemic is raising new and challenging ethical issues for researchers. If you have questions regarding research ethics, clinical ethics, or bioethics, please feel free to contact the Office of Research Integrity and we will do our best to find resources that might help you in your research endeavors.

Running a Lab in the New Normal: Dr. Adam Leventhal, Director of the University of Southern California’s Institute for Addiction Science, highlights the impact of COVID-19 on research labs across the country. His experience as a PI of multiple labs, advice from colleagues, and #AcademicTwitter all contribute to the key takeaways in this presentation including best practices for running a lab remotely, tips for adapting to the COVID-19 related structural and emotional changes, and ways to pivot and be flexible along the way. Watch the video on YouTube.

Societal Experts Action Network: The COVID-19 pandemic and the associated recession have significantly affected women’s workforce participation. While these impacts have varied by sector and family status, Black and Hispanic women have been particularly affected, bringing into sharp relief historical gender and racial inequities in the labor market. New guidance from the Societal Experts Action Network identifies strategies that state and local decision makers can use to assist in short-term recovery efforts for women whose employment status and work experiences have been affected by the COVID-19 pandemic. Learn more here.

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COVID-19 Core Facilities

To add your information, please click here.
If you have questions about a core facility’s operations or status, please contact the core facility.

Biosafety Level 3 Laboratories – Jill Henley
To get involved in research using the COVID-19 virus in BSL3 Containment Facility, please see here for an oversight committee for prioritized use of BSL3 facilities.  At this point facilities are available only for in vitro cell culture studies, not in vivo animal models. Proposing research groups beed to have their staff trained and certified to conduct the research.   To initiate the application process, email:

Tom Buchanan, Vice Dean for Research, Keck School of Medicine
Lucio Comai, Director, Hasting and Wright Foundation BSL3 Lab, KSOM
Jill Henley, Manger, Hastings and Wright Foundation BSL3 Lab, KSOM

BSL3 Containment Facility Services include SOP training, work flow guidance, sample storage and basic laboratory equipment. All research involving COVID-19 virus (SARS-CoV-2), including clinical specimens that might contain the virus, must be reviewed and approved by the USC Institutional Biosafety Committee.

Center for Economic and Social Rights (CESR) – Tania Gutsche
COVID-19 Health Tracking Poll to online panel of both National and LA County residents

Center for Peptide and Protein Engineering (CPPE) – CPPE
The CPPE provides ala carte and comprehensive peptide synthesis and purification services for the USC and general community.

Center of Excellence in NanoBiophysics – Shuxing Li
For the new test kit and compound design and development, the Center provide instruments including Microplate reader, Biacore, ITC to study the interaction between protein-protein, protein-compound and protein-DNA.

Choi Family Therapeutic Screening Facility – Mickey Huang
High Content Screening (HCS) and High Throughput Screening (HTS)

CTSI – Biostatistics, Epidemiology and Research Design (BERD) – Wendy Mack
The BERD team can assist investigators with the conduct, interpretation and summary of statistical analyses.

CTSI – Clinical Research Informatics (CRI) – Neil Bahroos
CRI provides services enabling complete access and analysis of patient data from the electronic medical records of Keck Medicine of USC, Children’s Hospital of Los Angeles, and the Los Angeles Department of Health Services.

CTSI – Clinical Research Support (CRS) – Tali Homsey
Clinical Research Coordinator Pool who provide study-related services ranging from regulatory document preparation, participant recruitment, data collection and entry, and study monitoring.

CTSI – Clinical Trials Unit (CTU) – Thao Rodriguez
The CTU employs highly qualified research staff to meet all of your human study needs, such as skilled research nurses, research phlebotomists, lab technicians, and radiology technicians.

Histology Lab – Junji Watanabe
Histology services including tissue processing, embedding, sectioning and H&E staining.

Immune Monitoring Core Diane Da Silva
Cytokine multiplex assays, clinical sample processing, functional lymphocyte assessment.

Keck Genomics Platform – Zarko Manojlovic
Genomics has essentially become the center of discovery and translational research across the globe. The importance of nucleic acid perturbations are all but ubiquitous as we move to understand the etiology of most human diseases and conditions. The ability to understand such complex conditions at its core will ultimately contribute to improvements in medical treatments and healthier communities.

Lentiviral LabLiana Asatryan
Recombinant lentivirus preparations, cell line generation.

Molecular Genomics Core – John Carpten
Molecular Genomics Core has Qiacube for viral RNA extraction.

Research Center for Liver Disease Analytical-Metabolomics-Instrumentation Core – Heather Johnson
qRT-PCR machines

Translational Imaging Center – Jason Junge
Live imaging of infected cells and tissues, including metabolic imaging. Stryker Treacheoscope for metabolic imaging in human airways. Olympus Bronchoscope for metabolic imaging of airways of animal models.

Translational Research Laboratory (TRLab) – Junji Watanabe
TRLab is equipped with over 50 specialized instruments in applications of: 1) automated sample processing (KingFisher, Pipet Robot), 2) Histology, 3) cell and Immunobiology (MSD, Luminex, Seahorse), 4) flow cytometry (analyzer & sorter), 5) imaging (microscopes, HTS plate/slide scan), 6) molecular analysis (plate readers, spectrometers), 7) Molecular Biology (Qubit, Bioanalyzer, TapeStation, qPCR) and 8) sequencing (MiSeq NGS).

USC COVID-19 Biospecimen Repository – Sue Ellen Martin
Procurement, processing, and storage of biospecimens from patients and appropriate controls to support researcch on COVID-19 in a CAP/CLIA certified environment. Biospecimens to include bronchial washings and brushings, bronchial FNA and core biopsy specimens, whole blood, serum, plasma, peripheral blood mononuclear cells, other as requested.

USC Genome Core – Daniel Campo
Library Preparation, Next-Generation Sequencing.

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Manufacturing Masks & Face Shields

Please look here for the latest information on manufacturing masks and face shields at USC.

Iovine and Young Academy MakerspaceJacob Patapoff
3-D Printing

Viterbi/Dornsife Machine ShopSeth Wieman
3-D Printing

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Donations of PPE

USC’s Department of Environmental Health & Safety (EH&S) and the Office of Research are reaching out to invite you to donate personal protective equipment (PPE) to support continued health care delivery at our Keck Hospital and other local healthcare organizations, first responders, Department of Public Safety, and critical clinical USC COVID-19 research activities. Learn more in the memo Personal Protective Equipment (PPEs).

To donate PPEs specifically to the Keck School of Medicine and its healthcare workers: On USC’s Coronavirus FAQ website, https://sites.usc.edu/coronavirus/faq/, they link to the items requested here or you can contract them via email DonateProtectiveGear@med.usc.edu for more information.

Learn more about USC’s efforts to help at Information about 3D-Printed Face Masks & Shields.

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