The USC Machine Learning Center, MASCLE for short, is a research center dedicated to fundamental machine learning and artificial intelligence research and education. Established in 2016, the mission of MASCLE is to advance convergent and synergistic activities between researchers in core machine learning and artificial intelligence across USC campus, and serve as the main hub of building interdisciplinary research of applying machine learning to applications to our society, including but not limited to sustainability, biology, health/medicine, and business.