The USC Big Data in Biotransport Center has been established as a platform to generate a rich database of AI/ML/DL predictive models that can be translated clinically for early diagnostics, improved treatment and monitoring of diverse ocular disorders (e.g., AMD, glaucoma, dry eye, diabetic retinopathy). Advanced machine-learning algorithms will give physicians new tools to better care for patients with ocular ailments. The algorithms will expedite individualized care by making it possible to analyze enormous volumes of data on patients with ocular diseases.