CNT3D has been established as a cutting-edge research center focused on applying breakthrough technologies in synthetic and medicinal chemistry, structural biology, computational chemistry, and machine learning/AI to drug discovery and development (3D). One of the key platforms of the center includes V-SYNTHES, a giga-scale structure-based virtual screening technology for hit and lead discovery (Nature 2021). The center is animated by a multidisciplinary group of Dornsife PIs, who lead the development and application of advanced 3D platforms to address a wide range of targets and therapeutic indications. CNT3D goal is to serve USC biomedical community by facilitating cost-effective and well-curated entry points into drug discovery at the molecular level.