The continued and rapid growth of E-commerce has generated questions about the consequences for society, business, and the global economy. The USC Marshall Initiative on Digital Competition, starting in January 2021, aims to discover insights on these questions through a collaboration of industry practitioners and academics from business disciplines as well as non-business disciplines (e.g. computer science, economics, law, communications); and disseminate these insights to a broad set of audiences that includes academics, business leaders, and the public.